However, this is a route that is easiest to achieve through deals with the devil, as they show up in boths pools. Guppy is generally considered one of the best game states to be in, even if it comes with a set of challenges. To contrast, red chests basically only give you a chance to become guppy. To top it off, since we do not spend HP on deals with the devil, the benefits of soul hearts as an option are reduced in effectiveness, as a higher health (from not spending it, plus eternal hearts) means that the value of soul hearts (and thus, the room in general, mitre, relic) is reduced, which reduces the value of the room if a player is seeking it out purposefully. Granted, some of the better items in the angel room are extremely desirable, some of those are are middling to overlapping (Dead Dove vs Spirit of the Night, Dark Bum vs Mitre). If we look at the Angel pool, it's polluted with many items that are unlikely to be wanted in a typical run (see: Bible, The Soul (compare to 3 soul heart room spawn instead), Rosary ( see prior two), Dead Sea Scrolls). Since red chests can contain deal items, from classic to rebirth, we now have a heavy bias toward Devil Deals in terms of average value. 1 item, 2 eternal hearts (arguably a 'food'), or 3 spirit hearts, and some assortment of blue fires for potential soul hearts.1 deal, 1 deal and 2 black hearts, 2 deals, 2 deals and a red chest, 3 deals, 3 red chests.So, if we compare Classic to Rebirth, we have gone from So, after trying to 100% everything, getting all the angel room items was one of the specific challenges to overcome, so the subjective data I've gotten from doing that has been nagging at me in some way, and I'm curious if the following makes sense to others.

Binding of isaac rebirth mitre